VETRAM INJ


Each Vial Contains:
Tramadol 50 mg

10 IN A TRAY Rs 24

VETRAM INJ

Tramadol Injection is a pain relieving medicine. It is used to manage persistent, moderate to severe chronic pain that requires continuous, around-the-clock treatment.
Tramadol differs from other traditional opioid medications in that it doesn't just act as a μ-opioid agonist, but also affects monoamines by modulating the effects of neurotransmitters involved in the modulation of pain such as serotonin and norepinpehrine which activate descending pain inhibitory pathways.

  • Moderate to severe pain

Mechanism of action-

Tramadol is a centrally acting μ-opioid receptor agonist and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to codeine and morphine. Tramadol binds weakly to κ- and δ-opioid receptors and to the μ-opioid receptor with 6000-fold less affinity than morphine.

Tramadol exists as a racemic mixture consisting of two pharmacologically active enantiomers that both contribute to its analgesic property through different mechanisms: (+)-tramadol and its primary metabolite (+)-O-desmethyl-tramadol (M1) are agonists of the μ opioid receptor while (+)-tramadol inhibits serotonin reuptake and (-)-tramadol inhibits norepinephrine reuptake. These pathways are complementary and synergistic, improving tramadol's ability to modulate the perception of and response to pain.

Pharmacokinetics-

  • Tramadol is rapidly and almost completely absorbed following intramuscular administration.
  • The volume of distribution of tramadol is reported to be in the range of 2.6-2.9 L/kg.
  • About 20% of the administered dose is found to bind to plasma proteins.
  • Tramadol undergoes extensive first-pass metabolism in the liver by N- and O- demethylation and conjugation. 
  • Tramadol is eliminated primarily through metabolism by the liver and the metabolites are excreted primarily by the kidneys, accounting for 90% of the excretion while the remaining 10% is excreted through feces.
  • Tramadol reported a half-life of 5-6 hours while the O-desmethyl-tramadol metabolite presents a half-life of 8 hours
    • Common side effect of tramadol includes:
    • Redness, and swelling at the injection site
    • Headache
    • Drowsiness
    • Fatigue
    • Vomiting
    • Constipation
    • Dry mouth
    • Sweating
    Do not use this injection in the following conditions:
    • Decreased function of the adrenal gland
    • Asthma
    • A low seizure threshold
    • Benzodiazepine overdose
    • Kidney disease with likely reduction in kidney function
    • Inherited dysfunction of autonomic nerve function
    Following drugs may interact with tramadol:
    • Sertraline
    • Cetirizine
    • Alprazolam
    • Warfarin
    • Pregabalin
    • Hydrocodone
    • Gabapentin
    • Duloxetine
    • Diphenhydramine
    • Zolpidem